Nobs, S. P. & Kopf, M. Tissue-resident macrophages: guardians of organ homeostasis. Trends Immunol. 42, 495–507 (2021).
Minutti, C. M., Knipper, J. A., Allen, J. E. & Zaiss, D. Tissue-specific contribution of macrophages to wound healing. Semin. Cell Dev. Biol. 61, 3–11 (2017).
Vannella, K. M. & Wynn, T. A. Mechanisms of organ injury and repair by macrophages. Ann. Rev. Physiol. 79, 593–617 (2016).
Chakarov, S. et al. Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. Science 363, eaau0964 (2019).
Wu, Y. & Hirschi, K. K. Tissue-resident macrophage development and function. Front. Cell Dev. Biol. 8, 617879 (2021).
van Beek, A. A., van den Bossche, J., Mastroberardino, P. G., de Winther, M. P. J. & Leenen, P. J. M. Metabolic alterations in aging macrophages: ingredients for inflammaging? Trends Immunol. 40, 113–127 (2019).
Franceschi, C., Garagnani, P., Vitale, G., Capri, M. & Salvioli, S. Inflammaging and ‘garb-aging’. Trends Endocrinol. Metab. 28, 199–212 (2017).
Mass, E., Nimmerjahn, F., Kierdorf, K. & Schlitzer, A. Tissue-specific macrophages: how they develop and choreograph tissue biology. Nat. Rev. Immunol. 23, 563–579 (2023).
Bruttger, J. et al. Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system. Immunity 43, 92–106 (2015).
Sakai, M. et al. Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity. Immunity 51, 655–670 (2019).
Hashimoto, D. et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38, 792–804 (2013).
Okabe, Y. & Medzhitov, R. Tissue biology perspective on macrophages. Nat. Immunol. 17, 9–17 (2016).
Guilliams, M., Thierry, G. R., Bonnardel, J. & Bajenoff, M. Establishment and maintenance of the macrophage niche. Immunity 52, 434–451 (2020).
Fukada, K. & Kajiya, K. Age-related structural alterations of skeletal muscles and associated capillaries. Angiogenesis 23, 79–82 (2020).
Grunewald, M. et al. Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. Science 373, eabc8479 (2021).
Pluvinage, J. V. & Wyss-Coray, T. Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration. Nat. Rev. Neurosci. 21, 93–102 (2020).
Shaw, A. C., Goldstein, D. R. & Montgomery, R. R. Age-dependent dysregulation of innate immunity. Nat. Rev. Immunol. 13, 875–887 (2013).
Pineda, C. M. et al. Intravital imaging of hair follicle regeneration in the mouse. Nat. Protoc. 10, 1116–1130 (2015).
Mesa, K. R. et al. Homeostatic epidermal stem cell self-renewal is driven by local differentiation. Cell Stem Cell 23, 677–686 (2018).
Dick, S. A. et al. Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles. Sci. Immunol. 7, eabf7777 (2022).
Siret, C. et al. Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain. Nat. Commun. 13, 7366 (2022).
A-Gonzalez, N. et al. Phagocytosis imprints heterogeneity in tissue-resident macrophages. J. Exp. Med. 214, 1281–1296 (2017).
Dietzel, S. et al. Label-free determination of hemodynamic parameters in the microcirculaton with third harmonic generation microscopy. PLoS ONE 9, e99615 (2014).
Saytashev, I. et al. Multiphoton excited hemoglobin fluorescence and third harmonic generation for non-invasive microscopy of stored blood. Biomed. Opt. Express 7, 3449 (2016).
Bentov, I. & Reed, M. J. The effect of aging on the cutaneous microvasculature. Microvasc. Res. 100, 25–31 (2015).
Smith, L. Histopathologic characteristics and ultrastructure of aging skin. Cutis 43, 414–424 (1989).
Li, L. et al. Age-related changes of the cutaneous microcirculation in vivo. Gerontology 52, 142–153 (2006).
Reeson, P., Choi, K. & Brown, C. E. VEGF signaling regulates the fate of obstructed capillaries in mouse cortex. eLife 7, e33670 (2018).
Das, A. et al. Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging. Cell 173, 74–89 (2018).
Tsuchida, Y. The effect of aging and arteriosclerosis on human skin blood flow. J. Dermatol. Sci. 5, 175–181 (1993).
Abdellatif, M., Rainer, P. P., Sedej, S. & Kroemer, G. Hallmarks of cardiovascular ageing. Nat. Rev. Cardiol. 20, 754–777 (2023).
Uderhardt, S., Martins, A. J., Tsang, J. S., Lämmermann, T. & Germain, R. N. Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage. Cell 177, 541–555 (2019).
Freeman, S. A. et al. Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. Science 367, 301–305 (2020).
Arandjelovic, S. & Ravichandran, K. S. Phagocytosis of apoptotic cells in homeostasis. Nat. Immunol. 16, 907–917 (2015).
Westman, J., Grinstein, S. & Marques, P. E. Phagocytosis of necrotic debris at sites of injury and inflammation. Front. Immunol. 10, 3030 (2020).
Lämmermann, T. et al. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498, 371–375 (2013).
Sasmono, R. T. et al. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J. Leucoc. Biol. 82, 111–123 (2007).
Lim, K. et al. In situ neutrophil efferocytosis shapes T cell immunity to influenza infection. Nat. Immunol. 21, 1046–1057 (2020).
Egen, J. G. et al. Macrophage and T cell dynamics during the development and disintegration of Mycobacterial Granulomas. Immunity 28, 271–284 (2008).
Cox, D. et al. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J. Exp. Med. 186, 1487–1494 (1997).
Perdiguero, E. & Geissmann, F. The development and maintenance of resident macrophages. Nat. Immunol. 17, 2–8 (2015).
Blériot, C., Chakarov, S. & Ginhoux, F. Determinants of resident tissue macrophage identity and function. Immunity 52, 957–970 (2020).
Alfituri, O. A., Mararo, E. M., Steketee, P. C., Morrison, L. J. & Mabbott, N. A. Dermal bacterial LPS-stimulation reduces susceptibility to intradermal Trypanosoma brucei infection. Sci. Rep. 11, 9856 (2021).
Gow, D. J. et al. Characterisation of a novel Fc conjugate of macrophage colony-stimulating factor. Mol. Ther. 22, 1580–1592 (2014).
Keshvari, S. et al. Therapeutic potential of macrophage colony-stimulating factor in chronic liver disease. Dis. Model. Mech. 15, dmm049387 (2022).
Zhou, X. et al. Circuit design features of a stable two-cell system. Cell 172, 744–757 (2018).
Nicolás-Ávila, J. A. et al. A network of macrophages supports mitochondrial homeostasis in the heart. Cell 183, 94–109 (2020).
Ferrer, I. R. et al. A wave of monocytes is recruited to replenish the long-term Langerhans cell network after immune injury. Sci. Immunol. 4, eaax8704 (2019).
Hasegawa, T. et al. Reduction in human epidermal Langerhans cells with age is associated with decline in CXCL14-mediated recruitment of CD14+ monocytes. J. Invest. Dermatol. 140, 1327–1334 (2019).
Fenske, N. A. & Lober, C. W. Structural and functional changes of normal aging skin. J. Am. Acad. Dermatol. 15, 571–585 (1986).
Chtanova, T. et al. Dynamics of neutrophil migration in lymph nodes during infection. Immunity 29, 487–496 (2008).
Voisin, B. et al. Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin. Immunity 56, 1561–1577 (2023).
Vollmers, A. C. et al. Dermatopontin-expressing fibroblasts mediate an essential skin macrophage niche. Preprint at bioRxiv https://doi.org/10.1101/2024.11.21.624708 (2024).
Marsh, E., Gonzalez, D. G., Lathrop, E. A., Boucher, J. & Greco, V. Positional stability and membrane occupancy define skin fibroblast homeostasis in vivo. Cell 175, 1620–1633 (2018).
Varani, J. et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J. Invest. Dermatol. 114, 480–486 (2000).
Cai, C. et al. Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain. Nat. Aging 3, 173–184 (2023).
Luche, H., Weber, O., Nageswara Rao, T., Blum, C. & Fehling, H. J. Faithful activation of an extra‐bright red fluorescent protein in “knock‐in” Cre‐reporter mice ideally suited for lineage tracing studies. Eur. J. Immunol. 37, 43–53 (2007).
Parkhurst, C. N. et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155, 1596–1609 (2013).
Jung, S. et al. Analysis of fractalkine receptor CX 3 CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106–4114 (2000).
Diehl, G. E. et al. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells. Nature 494, 116–120 (2013).
نشر لأول مرة على: www.nature.com
تاريخ النشر: 2025-10-15 03:00:00
الكاتب: Kailin R. Mesa
تنويه من موقع “yalebnan.org”:
تم جلب هذا المحتوى بشكل آلي من المصدر:
www.nature.com
بتاريخ: 2025-10-15 03:00:00.
الآراء والمعلومات الواردة في هذا المقال لا تعبر بالضرورة عن رأي موقع “yalebnan.org”، والمسؤولية الكاملة تقع على عاتق المصدر الأصلي.
ملاحظة: قد يتم استخدام الترجمة الآلية في بعض الأحيان لتوفير هذا المحتوى.
موقع "yalebnan" منصة لبنانية تجمع آخر الأخبار الفنية والاجتماعية والإعلامية لحظة بلحظة، مع تغطية حصرية ومواكبة لأبرز نجوم لبنان والعالم العربي.