Tang, X., Jaenisch, R. & Sur, M. The role of GABAergic signalling in neurodevelopmental disorders. Nat. Rev. Neurosci. 22, 290–307 (2021).
Google Scholar
Tremblay, R., Lee, S. & Rudy, B. GABAergic interneurons in the neocortex: from cellular properties to circuits. Neuron 91, 260–292 (2016).
Google Scholar
Hu, J. S., Vogt, D., Sandberg, M. & Rubenstein, J. L. Cortical interneuron development: a tale of time and space. Development 144, 3867–3878 (2017).
Google Scholar
Wang, Q. et al. The Allen Mouse Brain Common Coordinate Framework: a 3D reference atlas. Cell 181, 936–953 (2020).
Google Scholar
Swanson, L. W. Brain Architecture: Understanding the Basic Plan (Oxford Univ. Press, 2012).
Lim, L., Mi, D., Llorca, A. & Marín, O. Development and functional diversification of cortical interneurons. Neuron 100, 294–313 (2018).
Google Scholar
Flames, N. et al. Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J. Neurosci. 27, 9682–9695 (2007).
Google Scholar
Fragkouli, A., van Wijk, N. V., Lopes, R., Kessaris, N. & Pachnis, V. LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons. Development 136, 3841–3851 (2009).
Google Scholar
Anderson, S. A., Eisenstat, D. D., Shi, L. & Rubenstein, J. L. Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes. Science 278, 474–476 (1997).
Google Scholar
Nóbrega-Pereira, S. et al. Origin and molecular specification of globus pallidus neurons. J. Neurosci. 30, 2824–2834 (2010).
Google Scholar
Tufo, C. et al. Development of the mammalian main olfactory bulb. Development 149, dev200210 (2022).
Google Scholar
Li, J. et al. Transcription factors Sp8 and Sp9 coordinately regulate olfactory bulb interneuron development. Cereb. Cortex 28, 3278–3294 (2018).
Google Scholar
Bandler, R. C., Mayer, C. & Fishell, G. Cortical interneuron specification: the juncture of genes, time and geometry. Curr. Opin. Neurobiol. 42, 17–24 (2017).
Google Scholar
Turrero García, M. & Harwell, C. C. Radial glia in the ventral telencephalon. FEBS Lett. 591, 3942–3959 (2017).
Google Scholar
Schmitz, M. T. et al. The development and evolution of inhibitory neurons in primate cerebrum. Nature 603, 871–877 (2022).
Google Scholar
Yao, Z. et al. A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain. Nature 624, 317–332 (2023).
Google Scholar
Lim, D. A. & Alvarez-Buylla, A. The adult ventricular-subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis. Cold Spring Harb. Perspect. Biol. 8, a018820 (2016).
Google Scholar
Cebrian-Silla, A. et al. Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis. eLife 10, e67436 (2021).
Google Scholar
Batista-Brito, R., Close, J., Machold, R. & Fishell, G. The distinct temporal origins of olfactory bulb interneuron subtypes. J. Neurosci. 28, 3966–3975 (2008).
Google Scholar
Tepe, B. et al. Single-cell RNA-seq of mouse olfactory bulb reveals cellular heterogeneity and activity-dependent molecular census of adult-born neurons. Cell Rep. 25, 2689–2703 (2018).
Google Scholar
Gelman, D. et al. A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area. J. Neurosci. 31, 16570–16580 (2011).
Google Scholar
Yao, Z. et al. A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation. Cell 184, 3222–3241 (2021).
Google Scholar
Gouwens, N. W. et al. Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells. Cell 183, 935–953 (2020).
Google Scholar
Pelkey, K. A. et al. Hippocampal GABAergic inhibitory interneurons. Physiol. Rev. 97, 1619–1747 (2017).
Google Scholar
Urrutia-Piñones, J., Morales-Moraga, C., Sanguinetti-González, N., Escobar, A. P. & Chiu, C. Q. Long-range GABAergic projections of cortical origin in brain function. Front. Syst. Neurosci. 16, 841869 (2022).
Google Scholar
Luo, X. et al. Transcriptomic profile of the subiculum-projecting VIP GABAergic neurons in the mouse CA1 hippocampus. Brain Struct. Funct. 224, 2269–2280 (2019).
Google Scholar
Frazer, S. et al. Transcriptomic and anatomic parcellation of 5-HT3AR expressing cortical interneuron subtypes revealed by single-cell RNA sequencing. Nat. Commun. 8, 14219 (2017).
Google Scholar
Fisher, J. et al. Cortical somatostatin long-range projection neurons and interneurons exhibit divergent developmental trajectories. Neuron https://doi.org/10.1016/j.neuron.2023.11.013 (2023).
Fang, L. Z. & Creed, M. C. Updating the striatal-pallidal wiring diagram. Nat. Neurosci. 27, 15–27 (2024).
Google Scholar
Courtney, C. D., Pamukcu, A. & Chan, C. S. Cell and circuit complexity of the external globus pallidus. Nat. Neurosci. 26, 1147–1159 (2023).
Google Scholar
Turrero García, M. et al. Transcriptional profiling of sequentially generated septal neuron fates. eLife 10, e71545 (2021).
Google Scholar
Chen, R. et al. Decoding molecular and cellular heterogeneity of mouse nucleus accumbens. Nat. Neurosci. 24, 1757–1771 (2021).
Google Scholar
Tasic, B. et al. Shared and distinct transcriptomic cell types across neocortical areas. Nature 563, 72–78 (2018).
Google Scholar
Hegeman, D. J., Hong, E. S., Hernández, V. M. & Chan, C. S. The external globus pallidus: progress and perspectives. Eur. J. Neurosci. 43, 1239–1265 (2016).
Google Scholar
Abdi, A. et al. Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus. J. Neurosci. 35, 6667–6688 (2015).
Google Scholar
Stanley, G., Gokce, O., Malenka, R. C., Südhof, T. C. & Quake, S. R. Continuous and discrete neuron types of the adult murine striatum. Neuron 105, 688–699 (2020).
Google Scholar
Gokce, O. et al. Cellular taxonomy of the mouse striatum as revealed by single-cell RNA-seq. Cell Rep. 16, 1126–1137 (2016).
Google Scholar
Paxinos, G. & Franklin, K. B. J. Paxinos and Franklin’s the Mouse Brain in Stereotaxic Coordinates. (Academic, 2019).
Kuerbitz, J. et al. Loss of intercalated cells (ITCs) in the mouse amygdala of Tshz1 mutants correlates with fear, depression, and social interaction phenotypes. J. Neurosci. 38, 1160–1177 (2018).
Google Scholar
Waclaw, R. R., Ehrman, L. A., Pierani, A. & Campbell, K. Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse. J. Neurosci. 30, 6944–6953 (2010).
Google Scholar
Bandler, R. C. et al. Single-cell delineation of lineage and genetic identity in the mouse brain. Nature 601, 404–409 (2022).
Google Scholar
Pardo-Bellver, C., Cádiz-Moretti, B., Novejarque, A., Martínez-García, F. & Lanuza, E. Differential efferent projections of the anterior, posteroventral, and posterodorsal subdivisions of the medial amygdala in mice. Front. Neuroanat. 6, 33 (2012).
Google Scholar
Wang, Y. et al. Multimodal mapping of cell types and projections in the central nucleus of the amygdala. eLife 12, e84262 (2023).
Google Scholar
Nguyen, Q. A. T. et al. Hypothalamic representation of the imminence of predator threat detected by the vomeronasal organ in mice. eLife 12, RP92982 (2024).
Miller, S. M., Marcotulli, D., Shen, A. & Zweifel, L. S. Divergent medial amygdala projections regulate approach-avoidance conflict behavior. Nat. Neurosci. 22, 565–575 (2019).
Google Scholar
Knoedler, J. R. et al. A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell 185, 654–671 (2022).
Google Scholar
Raam, T. & Hong, W. Organization of neural circuits underlying social behavior: a consideration of the medial amygdala. Curr. Opin. Neurobiol. 68, 124–136 (2021).
Google Scholar
Hochgerner, H. et al. Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning. Nat. Neurosci. 26, 2237–2249 (2023).
Choi, G. B. et al. Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. Neuron 46, 647–660 (2005).
Google Scholar
Shemesh, Y. et al. Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. Nat. Neurosci. 19, 1489–1496 (2016).
Google Scholar
Pare, D. & Duvarci, S. Amygdala microcircuits mediating fear expression and extinction. Curr. Opin. Neurobiol. 22, 717–723 (2012).
Google Scholar
Hammack, S. E., Braas, K. M. & May, V. Chemoarchitecture of the bed nucleus of the stria terminalis: neurophenotypic diversity and function. Handb. Clin. Neurol. 179, 385–402 (2021).
Google Scholar
Forray, M. I. & Gysling, K. Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis. Brain Res. Rev. 47, 145–160 (2004).
Google Scholar
Rymar, V. V. & Sadikot, A. F. Laminar fate of cortical GABAergic interneurons is dependent on both birthdate and phenotype. J. Comp. Neurol. 501, 369–380 (2007).
Google Scholar
Valcanis, H. & Tan, S.-S. Layer specification of transplanted interneurons in developing mouse neocortex. J. Neurosci. 23, 5113–5122 (2003).
Google Scholar
Sultan, K. T. et al. Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex. Nat. Commun. 9, 4595 (2018).
Google Scholar
Besnard, A. & Leroy, F. Top-down regulation of motivated behaviors via lateral septum sub-circuits. Mol. Psychiatry 27, 3119–3128 (2022).
Google Scholar
Reid, C. M. et al. Multimodal classification of neurons in the lateral septum. Preprint at bioRxiv https://doi.org/10.1101/2024.02.15.580381 (2024).
Allaway, K. C. et al. Genetic and epigenetic coordination of cortical interneuron development. Nature 597, 693–697 (2021).
Google Scholar
La Manno, G. et al. Molecular architecture of the developing mouse brain. Nature 596, 92–96 (2021).
Google Scholar
Lee, D. R. et al. Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain. eLife 11, e71864 (2022).
Google Scholar
Mayer, C. et al. Developmental diversification of cortical inhibitory interneurons. Nature 555, 457–462 (2018).
Google Scholar
Kaplan, H. S. et al. Sensory input, sex and function shape hypothalamic cell type development. Nature https://doi.org/10.1038/s41586-025-08603-0 (2025).
Thompson, C. L. et al. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron 83, 309–323 (2014).
Google Scholar
Su-Feher, L. et al. Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia. Proc. Natl Acad. Sci. USA 119, e2108760119 (2022).
Google Scholar
Li, Z. et al. Transcription factor Sp9 is a negative regulator of D1-type MSN development. Cell Death Discov. 8, 301 (2022).
Google Scholar
García-Moreno, F. et al. A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei. Nat. Neurosci. 13, 680–689 (2010).
Google Scholar
Chen, Y.-J. J. et al. Use of “MGE enhancers” for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PLoS ONE 8, e61956 (2013).
Google Scholar
Taniguchi, H., Lu, J. & Huang, Z. J. The spatial and temporal origin of chandelier cells in mouse neocortex. Science 339, 70–74 (2013).
Google Scholar
Dehorter, N. et al. Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch. Science 349, 1216–1220 (2015).
Google Scholar
De Marco García, N. V., Karayannis, T. & Fishell, G. Neuronal activity is required for the development of specific cortical interneuron subtypes. Nature 472, 351–355 (2011).
Google Scholar
Huilgol, D. & Tole, S. Cell migration in the developing rodent olfactory system. Cell. Mol. Life Sci. 73, 2467–2490 (2016).
Google Scholar
Hobert, O. Regulatory logic of neuronal diversity: terminal selector genes and selector motifs. Proc. Natl Acad. Sci. USA 105, 20067–20071 (2008).
Google Scholar
Deneris, E. S. & Hobert, O. Maintenance of postmitotic neuronal cell identity. Nat. Neurosci. 17, 899–907 (2014).
Google Scholar
Harwell, C. C. et al. Wide dispersion and diversity of clonally related inhibitory interneurons. Neuron 87, 999–1007 (2015).
Google Scholar
Mayer, C. et al. Clonally related forebrain interneurons disperse broadly across both functional areas and structural boundaries. Neuron 87, 989–998 (2015).
Google Scholar
Tomioka, R. et al. Demonstration of long-range GABAergic connections distributed throughout the mouse neocortex. Eur. J. Neurosci. 21, 1587–1600 (2005).
Google Scholar
Paul, A. et al. Transcriptional architecture of synaptic communication delineates GABAergic neuron identity. Cell 171, 522–539 (2017).
Google Scholar
Stenman, J., Toresson, H. & Campbell, K. Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis. J. Neurosci. 23, 167–174 (2003).
Google Scholar
Xu, Z. et al. SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression. Development 145, dev165456 (2018).
Google Scholar
Wonders, C. P. et al. A spatial bias for the origins of interneuron subgroups within the medial ganglionic eminence. Dev. Biol. 314, 127–136 (2008).
Google Scholar
Risold, P. Y. & Swanson, L. W. Connections of the rat lateral septal complex. Brain Res. Rev. 24, 115–195 (1997).
Google Scholar
Calabresi, P., Picconi, B., Tozzi, A. & Di Filippo, M. Dopamine-mediated regulation of corticostriatal synaptic plasticity. Trends Neurosci. 30, 211–219 (2007).
Google Scholar
Jouvert, P. et al. Activation of the cGMP pathway in dopaminergic structures reduces cocaine-induced EGR-1 expression and locomotor activity. J. Neurosci. 24, 10716–10725 (2004).
Google Scholar
Hunnicutt, B. J. et al. A comprehensive excitatory input map of the striatum reveals novel functional organization. eLife 5, e19103 (2016).
Google Scholar
Magno, L. et al. NKX2-1 is required in the embryonic septum for cholinergic system development, learning, and memory. Cell Rep. 20, 1572–1584 (2017).
Google Scholar
Flandin, P. et al. Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron 70, 939–950 (2011).
Google Scholar
Chen, L., Chatterjee, M. & Li, J. Y. H. The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum. J. Neurosci. 30, 14824–14834 (2010).
Google Scholar
Higley, M. J. et al. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS ONE 6, e19155 (2011).
Google Scholar
Gielow, M. R. & Zaborszky, L. The input-output relationship of the cholinergic basal forebrain. Cell Rep. 18, 1817–1830 (2017).
Google Scholar
Gao, Y. et al. Continuous cell-type diversification in mouse visual cortex development. Nature https://doi.org/10.1038/s41586-025-09644-1 (2025).
Inta, D. et al. Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone. Proc. Natl Acad. Sci. USA 105, 20994–20999 (2008).
Google Scholar
Fishell, G. & Kepecs, A. Interneuron types as attractors and controllers. Annu. Rev. Neurosci. 43, 1–30 (2020).
Google Scholar
McInnes, L., Healy, J., Saul, N. & Großberger, L. UMAP: uniform manifold approximation and projection. J. Open Source Softw. 3, 861 (2018).
Google Scholar
Marchini, J. L., Heaton, C. & Ripley, B. D. fastICA: FastICA algorithms to perform ica and projection pursuit (2021); https://CRAN.R-project.org/package=fastICA
Andreatta, M. & Carmona, S. J. UCell: Robust and scalable single-cell gene signature scoring. Comput. Struct. Biotechnol. J. 19, 3796–3798 (2021).
Google Scholar
Singhal, V. et al. BANKSY unifies cell typing and tissue domain segmentation for scalable spatial omics data analysis. Nat. Genet. 56, 431–441 (2024).
Google Scholar
Johansen, N., Miller, J., Lee, C. & Kapen, I. AllenInstitute/Scrattch.Mapping: V0.55. Zenodo https://doi.org/10.5281/zenodo.10939013 (2024).
Allen Institute for Brain Science. Mouse whole cell tissue processing for 10x Genomics platform V.9. protocols.io https://doi.org/10.17504/protocols.io.q26g7b52klwz/v9 (2022).
Allen Institute for Brain Science. 10xV3 Genomics sample processing protocol. protocols.io https://doi.org/10.17504/protocols.io.bq7cmziw (2021).
Allen Institute for Brain Science. 10Xv3.1 Genomics sample processing. protocols.io https://doi.org/10.17504/protocols.io.dm6gpwd8jlzp/v3 (2024).
Yao, Z. et al. AllenInstitute/Scrattch.Hicat: Doi_release. Zenodo https://doi.org/10.5281/zenodo.11405898 (2024).
Lopez, R., Regier, J., Cole, M. B., Jordan, M. I. & Yosef, N. Deep generative modeling for single-cell transcriptomics. Nat. Methods 15, 1053–1058 (2018).
Google Scholar
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