📱 حمّل التطبيق
من لبنان لكل لبنان
اخبار الموقع
كريم نور يحيي سهرة مع Luxury Live Entertainment في مياميالشباب يسحق الأهلي بسداسية تاريخية.. هاتريك كاراسكو وأكبر نتيجة في تاريخ مواجهات الفريقيناكتشاف بترولي جديد في مصر.. بئر «لوركان-6» تضيف 1500 برميل نفط و8 ملايين قدم مكعب من الغاز يومياًفيضانات وسيول تضرب مناطق واسعة في سوريا.. 7 وفيات و4 مفقودين وأضرار جسيمة بالطرق والجسورمصر تشتري 6 شحنات من زيت الوقود وسط ضغوط واردات الطاقة وارتفاع فاتورة الغازوزارة الزراعة تنقذ ضبعاً برياً من مصيدة في عكار.. وتحذّر من استهداف الحيوانات البريةلبنان وقطر يستكملان مباحثات برنامج الطاقة المتكامل.. جولة رابعة في بيروت الأسبوع المقبلرونالدو يشعل الترند بثلاثية نارية أمام الخلود..
العلوم و التكنولوجيا

Thalamocoical transcriptional gates coordinate memory stabilization

, transcriptional, gates, coordinate, memory, stabilization

Thalamocortical, transcriptional, gates, coordinate, memory, stabilization

  • Yadav, N., Toader, A. & Rajasethupathy, P. Beyond hippocampus: thalamic and prefrontal contributions to an evolving memory. Neuron 112, 1045–1059 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Agranoff, B. W. & Klinger, P. D. Puromycin effect on memory fixation in the goldfish. Science 146, 952–953 (1964).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Flexner, L. B. & Flexner, J. B. Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice. Proc. Natl Acad. Sci. USA 55, 369–374 (1966).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Squire, L. R. & Barondes, S. H. Actinomycin-D: effects on memory at different times after training. Nature 225, 649–650 (1970).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Igaz, L. M., Vianna, M. R. M., Medina, J. H. & Izquierdo, I. Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning. J. Neurosci. 22, 6781–6789 (2002).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kandel, E. R. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294, 1030–1038 (2001).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Dash, P. K., Hochner, B. & Kandel, E. R. Injection of the cAMP-responsive element into the nucleus of aplysia sensory neurons blocks long-term facilitation. Nature 345, 718–721 (1990).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Alberini, C. M., Ghirardi, M., Metz, R. & Kandel, E. R. C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in aplysia. Cell 76, 1099–1114 (1994).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Yin, J. C. et al. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79, 49–58 (1994).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bourtchuladze, R. et al. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79, 59–68 (1994).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Silva, A. J., Kogan, J. H., Frankland, P. W. & Kida, S. CREB and memory. Annu. Rev. Neurosci. 21, 127–148 (1998).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Yin, J. C., Del Vecchio, M., Zhou, H. & Tully, T. CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81, 107–115 (1995).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bartsch, D., Casadio, A., Karl, K. A., Serodio, P. & Kandel, E. R. CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 95, 211–223 (1998).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Josselyn, S. A. et al. Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala. J. Neurosci. 21, 2404–2412 (2001).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Barco, A., Alarcon, J. M. & Kandel, E. R. Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108, 689–703 (2002).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lin, H.-W., Chen, C.-C., de Belle, J. S., Tully, T. & Chiang, A.-S. CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila. Proc. Natl Acad. Sci. USA 118, e2100624118 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lamprecht, R. & LeDoux, J. Structural plasticity and memory. Nat. Rev. Neurosci. 5, 45–54 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Carlezon, W. A. Jr, Duman, R. S. & Nestler, E. J. The many faces of CREB. Trends Neurosci. 28, 436–445 (2005).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kandel, E. R. The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB. Mol. Brain 5, 14 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nader, K. Memory traces unbound. Trends Neurosci. 26, 65–72 (2003).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Alberini, C. M. Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? Trends Neurosci. 28, 51–56 (2005).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Dudai, Y. Reconsolidation: the advantage of being refocused. Curr. Opin. Neurobiol. 16, 174–178 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wood, M. A., Hawk, J. D. & Abel, T. Combinatorial chromatin modifications and memory storage: a code for memory? Learn. Mem. 13, 241–244 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Coda, D. M. & Gräff, J. From cellular to fear memory: an epigenetic toolbox to remember. Curr. Opin. Neurobiol. 84, 102829 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kandel, E. R., Dudai, Y. & Mayford, M. R. The molecular and systems biology of memory. Cell 157, 163–186 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Holt, C. E., Martin, K. C. & Schuman, E. M. Local translation in neurons: visualization and function. Nat. Struct. Mol. Biol. 26, 557–566 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Frankland, P. W. & Bontempi, B. The organization of recent and remote memories. Nat. Rev. Neurosci. 6, 119–130 (2005).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Toader, A. C. et al. Anteromedial thalamus gates the selection and stabilization of long-term memories. Cell 186, 1369–1381.e17 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zeisel, A. et al. Molecular architecture of the mouse nervous system. Cell 174, 999–1014.e22 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yao, Z. et al. A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain. Nature 624, 317–332 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Heumos, L. et al. Pertpy: an end-to-end framework for perturbation analysis. Preprint at bioRxiv https://doi.org/10.1101/2024.08.04.606516 (2024).

  • Setty, M. et al. Characterization of cell fate probabilities in single-cell data with Palantir. Nat. Biotechnol. 37, 451–460 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Weiler, P., Lange, M., Klein, M., Pe’er, D. & Theis, F. CellRank 2: unified fate mapping in multiview single-cell data. Nat. Methods 21, 1196–1205 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Platt, R. J. et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell 159, 440–455 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dudai, Y., Jan, Y. N., Byers, D., Quinn, W. G. & Benzer, S. dunce, A mutant of Drosophila deficient in learning. Proc. Natl Acad. Sci. USA 73, 1684–1688 (1976).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Davis, R. L. Physiology and biochemistry of Drosophila learning mutants. Physiol. Rev. 76, 299–317 (1996).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Quinn, W. G., Sziber, P. P. & Booker, R. The Drosophila memory mutant amnesiac. Nature 277, 212–214 (1979).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Fusi, S., Drew, P. J. & Abbott, L. F. Cascade models of synaptically stored memories. Neuron 45, 599–611 (2005).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Marco, A. et al. Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble. Nat. Neurosci. 23, 1606–1617 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Santoni, G. et al. Chromatin plasticity predetermines neuronal eligibility for memory trace formation. Science 385, eadg9982 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Huentelman, M. J. et al. Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance. Hum. Mol. Genet. 16, 1469–1477 (2007).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Teixeira, J. R., Szeto, R. A., Carvalho, V. M. A., Muotri, A. R. & Papes, F. Transcription factor 4 and its association with psychiatric disorders. Transl. Psychiatry 11, 19 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Liu, H. et al. ASH1L mutation caused seizures and intellectual disability in twin sisters. J. Clin. Neurosci. 91, 69–74 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bintu, L. et al. Dynamics of epigenetic regulation at the single-cell level. Science 351, 720–724 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Larsen, S. B. et al. Establishment, maintenance, and recall of inflammatory memory. Cell Stem Cell 28, 1758–1774.e8 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Stern, S., Kirst, C. & Bargmann, C. I. Neuromodulatory control of long-term behavioral patterns and individuality across development. Cell 171, 1649–1662.e10 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Hergenreder, E. et al. Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02031-z (2024).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Campbell, R. R. & Wood, M. A. How the epigenome integrates information and reshapes the synapse. Nat. Rev. Neurosci. 20, 133–147 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mews, P. et al. From circuits to chromatin: the emerging role of epigenetics in mental health. J. Neurosci. 41, 873–882 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Grandi, F. C., Modi, H., Kampman, L. & Corces, M. R. Chromatin accessibility profiling by ATAC-seq. Nat. Protoc. 17, 1518–1552 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hrvatin, S. et al. Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat. Neurosci. 21, 120–129 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Nott, A., Schlachetzki, J. C. M., Fixsen, B. R. & Glass, C. K. Nuclei isolation of multiple brain cell types for omics interrogation. Nat. Protoc. 16, 1629–1646 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Azizi, E. et al. Single-cell map of diverse immune phenotypes in the breast tumor microenvironment. Cell 174, 1293–1308.e36 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: large-scale single-cell gene expression data analysis. Genome Biol. 19, 15 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wolock, S. L., Lopez, R. & Klein, A. M. Scrublet: computational identification of cell doublets in single-cell transcriptomic data. Cell Syst. 8, 281–291.e9 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Levine, J. H. et al. Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis. Cell 162, 184–197 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Phillips, J. W. et al. A repeated molecular architecture across thalamic pathways. Nat. Neurosci. 22, 1925–1935 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Finak, G. et al. MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol. 16, 278 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fang, Z., Liu, X. & Peltz, G. GSEApy: a comprehensive package for performing gene set enrichment analysis in Python. Bioinformatics 39, btac757 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Glasner, A. et al. Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies. Nat. Immunol. 24, 1020–1035 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dann, E., Henderson, N. C., Teichmann, S. A., Morgan, M. D. & Marioni, J. C. Differential abundance testing on single-cell data using k-nearest neighbor graphs. Nat. Biotechnol. 40, 245–253 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Keenan, A. B. et al. ChEA3: transcription factor enrichment analysis by orthogonal omics integration. Nucleic Acids Res. 47, W212–W224 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yao, Z. et al. Whole mouse brain transcriptomic cell type atlas — 10x scRNAseq whole brain (dataset). NeMO https://assets.nemoarchive.org/dat-qg7n1b0 (2023).


  • ■ مصدر الخبر الأصلي

    نشر لأول مرة على: www.nature.com

    تاريخ النشر: 2025-11-26 02:00:00

    الكاتب: Andrea Terceros

    تنويه من موقع “yalebnan.org”:

    تم جلب هذا المحتوى بشكل آلي من المصدر:
    www.nature.com
    بتاريخ: 2025-11-26 02:00:00.
    الآراء والمعلومات الواردة في هذا المقال لا تعبر بالضرورة عن رأي موقع “yalebnan.org”، والمسؤولية الكاملة تقع على عاتق المصدر الأصلي.

    ملاحظة: قد يتم استخدام الترجمة الآلية في بعض الأحيان لتوفير هذا المحتوى.

    yalebnan.org — متابعة الخبر