📱 حمّل التطبيق
من لبنان لكل لبنان
اخبار الموقع
مصر تشتري 6 شحنات من زيت الوقود وسط ضغوط واردات الطاقة وارتفاع فاتورة الغازوزارة الزراعة تنقذ ضبعاً برياً من مصيدة في عكار.. وتحذّر من استهداف الحيوانات البريةلبنان وقطر يستكملان مباحثات برنامج الطاقة المتكامل.. جولة رابعة في بيروت الأسبوع المقبلرونالدو يشعل الترند بثلاثية نارية أمام الخلود..الاحتلال يفجّر منزلي منفذي عملية فرش الهوى في الخليل.. وتهجير آلاف الفلسطينيين تحت وطأة العدواناعتداءات الاحتلال والمستوطنين تهدد موسم الزيتون في الضفة الغربية.. وتوقعات بخسارة نصف الإنتاجانتخابات الكنيست الإسرائيلي 2026: نتنياهو يتقدم ويفقد الأغلبية…الموت يفجع الممثل رودريغ سليمان برحيل والده إبراهيم سليمان… وكلمات مؤثرة تختصر وجع الفراق
العلوم و التكنولوجيا

Evolution of taste processing shifts dietary preference

, taste, processing, shifts, dietary, preference

Evolution, taste, processing, shifts, dietary, preference

  • Scott, K. Gustatory processing in Drosophila melanogaster. Annu. Rev. Entomol. 63, 15–30 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Auer, T. O., Shahandeh, M. P. & Benton, R. Drosophila sechellia: a genetic model for behavioral evolution and neuroecology. Annu. Rev. Genet. 55, 527–554 (2021).

  • Munch, D., Goldschmidt, D. & Ribeiro, C. The neuronal logic of how internal states control food choice. Nature 607, 747–755 (2022).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Yarmolinsky, D. A., Zuker, C. S. & Ryba, N. J. Common sense about taste: from mammals to insects. Cell 139, 234–244 (2009).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Policarpo, M., Baldwin, M. W., Casane, D. & Salzburger, W. Diversity and evolution of the vertebrate chemoreceptor gene repertoire. Nat. Commun. 15, 1421 (2024).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Li, R. et al. The sequence and de novo assembly of the giant panda genome. Nature 463, 311–317 (2010).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Li, X. et al. Pseudogenization of a sweet-receptor gene accounts for cats’ indifference toward sugar. PLoS Genet. 1, 27–35 (2005).

    Article 
    PubMed 

    Google Scholar 

  • Toda, Y. et al. Early origin of sweet perception in the songbird radiation. Science 373, 226–231 (2021).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Zhang, G. et al. Identification and expression profiles of gustatory receptor genes in Bactrocera minax larvae (Diptera: Tephritidae): role of BminGR59f in larval growth. Insect Sci. 29, 1240–1250 (2022).

    Article 
    PubMed 

    Google Scholar 

  • Yang, J. et al. Identification of a gustatory receptor tuned to sinigrin in the cabbage butterfly Pieris rapae. PLoS Genet. 17, e1009527 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fujii, S. et al. Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing. Curr. Biol. 25, 621–627 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Weiss, L. A., Dahanukar, A., Kwon, J. Y., Banerjee, D. & Carlson, J. R. The molecular and cellular basis of bitter taste in Drosophila. Neuron 69, 258–272 (2011).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Harris, D. T., Kallman, B. R., Mullaney, B. C. & Scott, K. Representations of taste modality in the Drosophila brain. Neuron 86, 1449–1460 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Li, J., Dhaliwal, R., Stanley, M., Junca, P. & Gordon, M. D. Functional imaging and connectome analyses reveal organizing principles of taste circuits in Drosophila. Curr. Biol. 35, 2391–2405 (2025).

  • Walker, S. R., Pena-Garcia, M. & Devineni, A. V. Connectomic analysis of taste circuits in Drosophila. Sci. Rep. 15, 5278 (2025).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tastekin, I. et al. From sensory detection to motor action: the comprehensive Drosophila taste-feeding connectome. Preprint at bioRxiv https://doi.org/10.1101/2025.08.25.671814 (2025).

  • Shiu, P. K., Sterne, G. R., Engert, S., Dickson, B. J. & Scott, K. Taste quality and hunger interactions in a feeding sensorimotor circuit. eLife 11, e79887 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Snell, N. J. et al. Complex representation of taste quality by second-order gustatory neurons in Drosophila. Curr Biol 32, 3758–3772 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cavey, M. et al. Increased sugar valuation contributes to the evolutionary shift in egg-laying behavior of the fruit pest Drosophila suzukii. PLoS Biol. 21, e3002432 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Pelaez, J. N. et al. Taste evolution in an herbivorous drosophilid. Preprint at bioRxiv https://doi.org/10.1101/2024.02.27.582299 (2024).

  • Wang, W. et al. Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii. eLife 11, e81703 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dweck, H. K., Talross, G. J., Wang, W. & Carlson, J. R. Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii. eLife 10, e81703 (2021).

    Article 

    Google Scholar 

  • Dweck, H. K. M. & Carlson, J. R. Molecular logic and evolution of bitter taste in Drosophila. Curr. Biol. 30, 17–30 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Dey, M., Brown, E., Charlu, S., Keene, A. & Dahanukar, A. Evolution of fatty acid taste in drosophilids. Cell Rep. 42, 113297 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • McBride, C. S. Rapid evolution of smell and taste receptor genes during host specialization in Drosophila sechellia. Proc. Natl Acad. Sci. USA 104, 4996–5001 (2007).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Matsuo, T., Sugaya, S., Yasukawa, J., Aigaki, T. & Fuyama, Y. Odorant-binding proteins OBP57d and OBP57e affect taste perception and host-plant preference in Drosophila sechellia. PLoS Biol. 5, 985–996 (2007).

    Article 

    Google Scholar 

  • Reisenman, C. E., Wong, J., Vedagarbha, N., Livelo, C. & Scott, K. Taste adaptations associated with host specialization in the specialist Drosophila sechellia. J. Exp. Biol. 226, jeb244641 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Auer, T. O. et al. Olfactory receptor and circuit evolution promote host specialization. Nature 579, 402–408 (2020).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Charlu, S., Wisotsky, Z., Medina, A. & Dahanukar, A. Acid sensing by sweet and bitter taste neurons in Drosophila melanogaster. Nat. Commun. 4, 2042 (2013).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Itskov, P. M. et al. Automated monitoring and quantitative analysis of feeding behaviour in Drosophila. Nat. Commun. 5, 4560 (2014).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Alvarez-Ocana, R. et al. Odor-regulated oviposition behavior in an ecological specialist. Nat. Commun. 14, 3041 (2023).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Task, D. et al. Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons. eLife 11, e72599 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Watanabe, K. et al. Interspecies comparative analyses reveal distinct carbohydrate-responsive systems among Drosophila species. Cell Rep. 28, 2594–2607 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Abe, M. et al. Shortened lifespan induced by a high-glucose diet is associated with intestinal immune dysfunction in Drosophila sechellia. J. Exp. Biol. 225, jeb244423 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Melvin, R. G. et al. Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis. eLife 7, e40841 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jacobs, R. V. et al. Overlap and divergence of neural circuits mediating distinct behavioral responses to sugar. Cell Rep. 43, 114782 (2024).

    Article 
    PubMed 

    Google Scholar 

  • Steck, K. et al. Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila. eLife 7, e31625 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • LeDue, E. E., Chen, Y. C., Jung, A. Y., Dahanukar, A. & Gordon, M. D. Pharyngeal sense organs drive robust sugar consumption in Drosophila. Nat. Commun. 6, 6667 (2015).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Chen, Y. D., Park, S. J., Joseph, R. M., Ja, W. W. & Dahanukar, A. A. Combinatorial pharyngeal taste coding for feeding avoidance in adult Drosophila. Cell Rep. 29, 961–973 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Guillemin, J. et al. Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila. Cell Rep. 43, 114625 (2024).

    Article 
    PubMed 

    Google Scholar 

  • Takagi, S. et al. Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking. Nat. Commun. 15, 7041 (2024).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sanchez-Alcaniz, J. A. et al. An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing. Nat. Commun. 9, 4252 (2018).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lima, D. B. M., Dos Santos, A. L., Cardoso, C. A. L., Krause, L. C. & Caramao, E. B. Studies related to the chemical composition, biological activities and toxicity of methanolic extracts of noni (Morinda citrifolia) fruits and leaves. Nat. Prod. Res. 36, 5868–5871 (2022).

    Article 
    PubMed 

    Google Scholar 

  • Tauber, J. M. et al. A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste. PLoS Genet. 13, e1007059 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ikeda, R., Wada, M., Nishigaki, T. & Nakashima, K. Quantification of coumarin derivatives in noni (Morinda citrifolia) and their contribution of quenching effect on reactive oxygen species. Food Chem. 113, 1169–1172 (2009).

  • Ahn, J. E., Chen, Y. & Amrein, H. Molecular basis of fatty acid taste in Drosophila. eLife 6, e30115 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Devineni, A. V., Deere, J. U., Sun, B. & Axel, R. Individual bitter-sensing neurons in Drosophila exhibit both ON and OFF responses that influence synaptic plasticity. Curr. Biol. 31, 5533–5546 (2021).

    Article 
    PubMed 

    Google Scholar 

  • Gardiner, A., Barker, D., Butlin, R. K., Jordan, W. C. & Ritchie, M. G. Evolution of a complex locus: exon gain, loss and divergence at the Gr39a locus in Drosophila. PLoS ONE 3, e1513 (2008).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jumper, J. et al. Highly accurate protein structure prediction with AlphaFold. Nature 596, 583–589 (2021).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ma, D. et al. Structural basis for sugar perception by Drosophila gustatory receptors. Science 383, eadj2609 (2024).

    Article 
    PubMed 

    Google Scholar 

  • Shiu, P. K. et al. A Drosophila computational brain model reveals sensorimotor processing. Nature 634, 210–219 (2024).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • McKellar, C. E., Siwanowicz, I., Dickson, B. J. & Simpson, J. H. Controlling motor neurons of every muscle for fly proboscis reaching. eLife 9, e54978 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gonzalez Segarra, A. J., Pontes, G., Jourjine, N., Del Toro, A. & Scott, K. Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion. eLife 12, RP88143 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Schlegel, P. et al. Information flow, cell types and stereotypy in a full olfactory connectome. eLife 10, e66018 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Prieto-Godino, L. L., Schmidt, H. R. & Benton, R. Molecular reconstruction of recurrent evolutionary switching in olfactory receptor specificity. eLife 10, e69732 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chu, B., Chui, V., Mann, K. & Gordon, M. D. Presynaptic gain control drives sweet and bitter taste integration in Drosophila. Curr. Biol. 24, 1978–1984 (2014).

    Article 
    PubMed 

    Google Scholar 

  • Inagaki, H. K., Panse, K. M. & Anderson, D. J. Independent, reciprocal neuromodulatory control of sweet and bitter taste sensitivity during starvation in Drosophila. Neuron 84, 806–820 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cui, X., Meiselman, M. R., Thornton, S. N. & Yapici, N. A gut-brain-gut interoceptive circuit loop gates sugar ingestion in Drosophila. Preprint at bioRxiv https://doi.org/10.1101/2024.09.02.610892 (2024).

  • Carvalho-Santos, Z. et al. Cellular metabolic reprogramming controls sugar appetite in Drosophila. Nat. Metab. 2, 958–973 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Ling, F., Dahanukar, A., Weiss, L. A., Kwon, J. Y. & Carlson, J. R. The molecular and cellular basis of taste coding in the legs of Drosophila. J. Neurosci. 34, 7148–7164 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Li, H. et al. Fly Cell Atlas: a single-nucleus transcriptomic atlas of the adult fruit fly. Science 375, eabk2432 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gohl, D. M. et al. A versatile in vivo system for directed dissection of gene expression patterns. Nat. Methods 8, 231–237 (2011).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Arnoult, L. et al. Emergence and diversification of fly pigmentation through evolution of a gene regulatory module. Science 339, 1423–1426 (2013).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Gratz, S. J. et al. Highly specific and efficient CRISPR/Cas9-catalyzed homology-directed repair in. Drosophila. Genetics 196, 961–971 (2014).

    PubMed 

    Google Scholar 

  • Port, F., Chen, H.-M., Lee, T. & Bullock, S. L. Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila. Proc. Natl Acad. Sci. USA 111, E2967–E2976 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bischof, J., Maeda, R. K., Hediger, M., Karch, F. & Basler, K. An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc. Natl Acad. Sci. USA 104, 3312–3317 (2007).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sanchez-Alcaniz, J. A., Zappia, G., Marion-Poll, F. & Benton, R. A mechanosensory receptor required for food texture detection in Drosophila. Nat. Commun. 8, 14192 (2017).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676–682 (2012).

    Article 
    PubMed 

    Google Scholar 

  • Cachero, S., Ostrovsky, A. D., Yu, J. Y., Dickson, B. J. & Jefferis, G. S. Sexual dimorphism in the fly brain. Curr. Biol. 20, 1589–1601 (2010).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ribeiro, C. & Dickson, B. J. Sex peptide receptor and neuronal TOR/S6K signaling modulate nutrient balancing in Drosophila. Curr. Biol. 20, 1000–1005 (2010).

    Article 
    PubMed 

    Google Scholar 

  • Yushkevich, P. A. et al. User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 31, 1116–1128 (2006).

    Article 
    PubMed 

    Google Scholar 

  • Mirdita, M. et al. ColabFold: making protein folding accessible to all. Nat. Methods 19, 679–682 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wickham, H. et al. Welcome to the tidyverse. J. Open Source Softw. 4, 1686 (2019).

    Article 
    ADS 

    Google Scholar 


  • ■ مصدر الخبر الأصلي

    نشر لأول مرة على: www.nature.com

    تاريخ النشر: 2025-11-26 02:00:00

    الكاتب: Enrico Bertolini

    تنويه من موقع “yalebnan.org”:

    تم جلب هذا المحتوى بشكل آلي من المصدر:
    www.nature.com
    بتاريخ: 2025-11-26 02:00:00.
    الآراء والمعلومات الواردة في هذا المقال لا تعبر بالضرورة عن رأي موقع “yalebnan.org”، والمسؤولية الكاملة تقع على عاتق المصدر الأصلي.

    ملاحظة: قد يتم استخدام الترجمة الآلية في بعض الأحيان لتوفير هذا المحتوى.

    yalebnan.org — متابعة الخبر