📱 حمّل التطبيق
من لبنان لكل لبنان
اخبار الموقع
كريم نور يحيي سهرة مع Luxury Live Entertainment في مياميالشباب يسحق الأهلي بسداسية تاريخية.. هاتريك كاراسكو وأكبر نتيجة في تاريخ مواجهات الفريقيناكتشاف بترولي جديد في مصر.. بئر «لوركان-6» تضيف 1500 برميل نفط و8 ملايين قدم مكعب من الغاز يومياًفيضانات وسيول تضرب مناطق واسعة في سوريا.. 7 وفيات و4 مفقودين وأضرار جسيمة بالطرق والجسورمصر تشتري 6 شحنات من زيت الوقود وسط ضغوط واردات الطاقة وارتفاع فاتورة الغازوزارة الزراعة تنقذ ضبعاً برياً من مصيدة في عكار.. وتحذّر من استهداف الحيوانات البريةلبنان وقطر يستكملان مباحثات برنامج الطاقة المتكامل.. جولة رابعة في بيروت الأسبوع المقبلرونالدو يشعل الترند بثلاثية نارية أمام الخلود..
العلوم و التكنولوجيا

Neutrophils preserve energy storage in sympatically activated adipocytes

Neutrophils preserve energy storage in sympatically activated adipocytes

  • Sakers, A., De Siqueira, M. K., Seale, P. & Villanueva, C. J. Adipose-tissue plasticity in health and disease. Cell 185, 419–446 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Reilly, S. M. & Saltiel, A. R. Adapting to obesity with adipose tissue inflammation. Nat. Rev. Endocrinol. 13, 633–643 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Saltiel, A. R. & Olefsky, J. M. Inflammatory mechanisms linking obesity and metabolic disease. J. Clin. Invest. 127, 1–4 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Rohm, T. V., Meier, D. T., Olefsky, J. M. & Donath, M. Y. Inflammation in obesity, diabetes, and related disorders. Immunity 55, 31–55 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Man, K., Kallies, A. & Vasanthakumar, A. Resident and migratory adipose immune cells control systemic metabolism and thermogenesis. Cell. Mol. Immunol. 19, 421–431 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wernstedt Asterholm, I. et al. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab. 20, 103–118 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Burn, G. L., Foti, A., Marsman, G., Patel, D. F. & Zychlinsky, A. The neutrophil. Immunity 54, 1377–1391 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Nemeth, T., Sperandio, M. & Mocsai, A. Neutrophils as emerging therapeutic targets. Nat. Rev. Drug Discov. 19, 253–275 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Herro, R. & Grimes, H. L. The diverse roles of neutrophils from protection to pathogenesis. Nat. Immunol. 25, 2209–2219 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kaplan, M. J. Of larks and owls. Nat. Immunol. 21, 104–105 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Janssen, H. et al. Monocytes re-enter the bone marrow during fasting and alter the host response to infection. Immunity 56, 783–796 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Brenner, I. K. et al. Immune changes in humans during cold exposure: effects of prior heating and exercise. J. Appl. Physiol. 87, 699–710 (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Cho, J. S. et al. Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog. 8, e1003047 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Swanson, K. V., Deng, M. & Ting, J. P. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat. Rev. Immunol. 19, 477–489 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179–188 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dror, E. et al. Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat. Immunol. 18, 283–292 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zhou, H. et al. IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes. Nat. Immunol. 21, 1219–1231 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hofwimmer, K. et al. IL-1β promotes adipogenesis by directly targeting adipocyte precursors. Nat. Commun. 15, 7957 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Roth Flach, R. J. et al. β3-adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation. J. Biol. Chem. 288, 2882–2892 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Silva, H. M. et al. Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. J. Exp. Med. 216, 786–806 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Watanabe, Y. et al. Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation. FASEB J. 33, 11821–11835 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Young, J. B., Saville, E., Rothwell, N. J., Stock, M. J. & Landsberg, L. Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat. J. Clin. Invest. 69, 1061–1071 (1982).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • King, V. L., Dwoskin, L. P. & Cassis, L. A. Cold exposure regulates the norepinephrine uptake transporter in rat brown adipose tissue. Am. J. Physiol. 276, R143–R151 (1999).

    CAS 
    PubMed 

    Google Scholar 

  • Liu, X., Perusse, F. & Bukowiecki, L. J. Mechanisms of the antidiabetic effects of the β3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats. Am. J. Physiol. 274, R1212–R1219 (1998).

    CAS 
    PubMed 

    Google Scholar 

  • Weyer, C., Gautier, J. F. & Danforth, E. Jr. Development of β3-adrenoceptor agonists for the treatment of obesity and diabetes-an update. Diabetes Metab. 25, 11–21 (1999).

    CAS 
    PubMed 

    Google Scholar 

  • Valentine, J. M. et al. β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J. Clin. Invest. https://doi.org/10.1172/JCI153357 (2022).

  • Muzzin, P. et al. An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity. J. Biol. Chem. 266, 24053–24058 (1991).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Nahmias, C. et al. Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J. 10, 3721–3727 (1991).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Carmen, G. Y. & Victor, S. M. Signalling mechanisms regulating lipolysis. Cell Signal. 18, 401–408 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Mottillo, E. P., Shen, X. J. & Granneman, J. G. β3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK. Biochim. Biophys. Acta 1801, 1048–1055 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cao, W. et al. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol. Cell. Biol. 24, 3057–3067 (2004).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Reilly, S. M. et al. Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat. Metab. 2, 620–634 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Metzemaekers, M., Gouwy, M. & Proost, P. Neutrophil chemoattractant receptors in health and disease: double-edged swords. Cell. Mol. Immunol. 17, 433–450 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Reber, L. L. et al. Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide. J. Exp. Med. 214, 1249–1258 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Flores, J., Noel, A., Foveau, B., Beauchet, O. & LeBlanc, A. C. Pre-symptomatic caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging. Nat. Commun. 11, 4571 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yang, X. et al. The G0/G1 switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab. 11, 194–205 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mowers, J. et al. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKepsilon and TBK1. eLife 2, e01119 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Reilly, S. M. et al. An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice. Nat. Med. 19, 313–321 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Koprulu, M. et al. Identification of rare loss-of-function genetic variation regulating body fat distribution. J. Clin. Endocrinol. Metab. 107, 1065–1077 (2022).

    Article 
    PubMed 

    Google Scholar 

  • Ortega-Gomez, A., Perretti, M. & Soehnlein, O. Resolution of inflammation: an integrated view. EMBO Mol. Med. 5, 661–674 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Soehnlein, O., Steffens, S., Hidalgo, A. & Weber, C. Neutrophils as protagonists and targets in chronic inflammation. Nat. Rev. Immunol. 17, 248–261 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Herrero-Cervera, A., Soehnlein, O. & Kenne, E. Neutrophils in chronic inflammatory diseases. Cell. Mol. Immunol. 19, 177–191 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Marzano, A. V. et al. Mechanisms of inflammation in neutrophil-mediated skin diseases. Front. Immunol. 10, 1059 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tang, H. N. et al. Plasticity of adipose tissue in response to fasting and refeeding in male mice. Nutr. Metab. 14, 3 (2017).

    Article 

    Google Scholar 

  • Ding, H. et al. Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16. Nat. Commun. 7, 11533 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Xia, W. et al. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nat. Metab. 6, 273–289 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Shin, H. et al. Lipolysis in brown adipocytes is not essential for cold-induced thermogenesis in mice. Cell Metab. 26, 764–777 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yang, X. et al. Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions. JCI Insight 2, e89044 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Griffin, M. J. On the immunometabolic role of NF-κB in adipocytes. Immunometabolism https://doi.org/10.20900/immunometab20220003 (2022).

  • Gao, D. et al. Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes. Am. J. Physiol. Endocrinol. Metab. 307, E289–E304 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Guo, Q. et al. NF-kappaB in biology and targeted therapy: new insights and translational implications. Signal Transduct. Target. Ther. 9, 53 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kahnt, A. S., Hafner, A. K. & Steinhilber, D. The role of human 5-Lipoxygenase (5-LO) in carcinogenesis—a question of canonical and non-canonical functions. Oncogene 43, 1319–1327 (2024).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Oyoshi, M. K. et al. Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity 37, 747–758 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Afonso, P. V. et al. LTB4 is a signal-relay molecule during neutrophil chemotaxis. Dev. Cell 22, 1079–1091 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Werz, O., Klemm, J., Samuelsson, B. & Radmark, O. 5-Lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. Proc. Natl Acad. Sci. USA 97, 5261–5266 (2000).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lee, Y. S., Wollam, J. & Olefsky, J. M. An integrated view of immunometabolism. Cell 172, 22–40 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Stienstra, R. et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc. Natl Acad. Sci. USA 108, 15324–15329 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hildebrandt, X., Ibrahim, M. & Peltzer, N. Cell death and inflammation during obesity: “know my methods, WAT(son)”. Cell Death Differ. 30, 279–292 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sakamoto, T. et al. Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice. Am. J. Physiol. Endocrinol. Metab. 310, E676–E687 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Zhao, P. et al. TBK1 at the crossroads of inflammation and energy homeostasis in adipose tissue. Cell 172, 731–743 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wisessaowapak, C. et al. Protocol for differentiating murine 3T3-L1 and SVF-derived preadipocytes and isolating crude mitochondrial fractions. STAR Protoc. 6, 104045 (2025).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhou, Y. et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun. 10, 1523 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhong, J. et al. adiposetissue.org: a knowledge portal integrating clinical and experimental data from human adipose tissue. Cell Metab. 37, 566–569 (2025).

    Article 
    CAS 
    PubMed 

    Google Scholar 


  • ■ مصدر الخبر الأصلي

    نشر لأول مرة على: www.nature.com

    تاريخ النشر: 2025-12-10 02:00:00

    الكاتب: Seunghwan Son

    تنويه من موقع “yalebnan.org”:

    تم جلب هذا المحتوى بشكل آلي من المصدر:
    www.nature.com
    بتاريخ: 2025-12-10 02:00:00.
    الآراء والمعلومات الواردة في هذا المقال لا تعبر بالضرورة عن رأي موقع “yalebnan.org”، والمسؤولية الكاملة تقع على عاتق المصدر الأصلي.

    ملاحظة: قد يتم استخدام الترجمة الآلية في بعض الأحيان لتوفير هذا المحتوى.

    yalebnan.org — متابعة الخبر