Thalamocortical transcriptional gates coordinate memory stabilization
Thalamocortical transcriptional gates coordinate memory stabilization
Yadav, N., Toader, A. & Rajasethupathy, P. Beyond hippocampus: thalamic and prefrontal contributions to an evolving memory. Neuron 112, 1045–1059 (2024).
Agranoff, B. W. & Klinger, P. D. Puromycin effect on memory fixation in the goldfish. Science 146, 952–953 (1964).
Flexner, L. B. & Flexner, J. B. Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice. Proc. Natl Acad. Sci. USA 55, 369–374 (1966).
Squire, L. R. & Barondes, S. H. Actinomycin-D: effects on memory at different times after training. Nature 225, 649–650 (1970).
Igaz, L. M., Vianna, M. R. M., Medina, J. H. & Izquierdo, I. Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning. J. Neurosci. 22, 6781–6789 (2002).
Kandel, E. R. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294, 1030–1038 (2001).
Dash, P. K., Hochner, B. & Kandel, E. R. Injection of the cAMP-responsive element into the nucleus of aplysia sensory neurons blocks long-term facilitation. Nature 345, 718–721 (1990).
Alberini, C. M., Ghirardi, M., Metz, R. & Kandel, E. R. C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in aplysia. Cell 76, 1099–1114 (1994).
Yin, J. C. et al. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79, 49–58 (1994).
Bourtchuladze, R. et al. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79, 59–68 (1994).
Silva, A. J., Kogan, J. H., Frankland, P. W. & Kida, S. CREB and memory. Annu. Rev. Neurosci. 21, 127–148 (1998).
Yin, J. C., Del Vecchio, M., Zhou, H. & Tully, T. CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81, 107–115 (1995).
Bartsch, D., Casadio, A., Karl, K. A., Serodio, P. & Kandel, E. R. CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 95, 211–223 (1998).
Josselyn, S. A. et al. Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala. J. Neurosci. 21, 2404–2412 (2001).
Barco, A., Alarcon, J. M. & Kandel, E. R. Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108, 689–703 (2002).
Lin, H.-W., Chen, C.-C., de Belle, J. S., Tully, T. & Chiang, A.-S. CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila. Proc. Natl Acad. Sci. USA 118, e2100624118 (2021).
Lamprecht, R. & LeDoux, J. Structural plasticity and memory. Nat. Rev. Neurosci. 5, 45–54 (2004).
Carlezon, W. A. Jr, Duman, R. S. & Nestler, E. J. The many faces of CREB. Trends Neurosci. 28, 436–445 (2005).
Kandel, E. R. The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB. Mol. Brain 5, 14 (2012).
Nader, K. Memory traces unbound. Trends Neurosci. 26, 65–72 (2003).
Alberini, C. M. Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? Trends Neurosci. 28, 51–56 (2005).
Dudai, Y. Reconsolidation: the advantage of being refocused. Curr. Opin. Neurobiol. 16, 174–178 (2006).
Wood, M. A., Hawk, J. D. & Abel, T. Combinatorial chromatin modifications and memory storage: a code for memory? Learn. Mem. 13, 241–244 (2006).
Coda, D. M. & Gräff, J. From cellular to fear memory: an epigenetic toolbox to remember. Curr. Opin. Neurobiol. 84, 102829 (2024).
Kandel, E. R., Dudai, Y. & Mayford, M. R. The molecular and systems biology of memory. Cell 157, 163–186 (2014).
Holt, C. E., Martin, K. C. & Schuman, E. M. Local translation in neurons: visualization and function. Nat. Struct. Mol. Biol. 26, 557–566 (2019).
Frankland, P. W. & Bontempi, B. The organization of recent and remote memories. Nat. Rev. Neurosci. 6, 119–130 (2005).
Toader, A. C. et al. Anteromedial thalamus gates the selection and stabilization of long-term memories. Cell 186, 1369–1381.e17 (2023).
Zeisel, A. et al. Molecular architecture of the mouse nervous system. Cell 174, 999–1014.e22 (2018).
Yao, Z. et al. A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain. Nature 624, 317–332 (2023).
Heumos, L. et al. Pertpy: an end-to-end framework for perturbation analysis. Preprint at bioRxiv https://doi.org/10.1101/2024.08.04.606516 (2024).
Setty, M. et al. Characterization of cell fate probabilities in single-cell data with Palantir. Nat. Biotechnol. 37, 451–460 (2019).
Weiler, P., Lange, M., Klein, M., Pe’er, D. & Theis, F. CellRank 2: unified fate mapping in multiview single-cell data. Nat. Methods 21, 1196–1205 (2024).
Platt, R. J. et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell 159, 440–455 (2014).
Dudai, Y., Jan, Y. N., Byers, D., Quinn, W. G. & Benzer, S. dunce, A mutant of Drosophila deficient in learning. Proc. Natl Acad. Sci. USA 73, 1684–1688 (1976).
Davis, R. L. Physiology and biochemistry of Drosophila learning mutants. Physiol. Rev. 76, 299–317 (1996).
Quinn, W. G., Sziber, P. P. & Booker, R. The Drosophila memory mutant amnesiac. Nature 277, 212–214 (1979).
Fusi, S., Drew, P. J. & Abbott, L. F. Cascade models of synaptically stored memories. Neuron 45, 599–611 (2005).
Marco, A. et al. Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble. Nat. Neurosci. 23, 1606–1617 (2020).
Santoni, G. et al. Chromatin plasticity predetermines neuronal eligibility for memory trace formation. Science 385, eadg9982 (2024).
Huentelman, M. J. et al. Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance. Hum. Mol. Genet. 16, 1469–1477 (2007).
Teixeira, J. R., Szeto, R. A., Carvalho, V. M. A., Muotri, A. R. & Papes, F. Transcription factor 4 and its association with psychiatric disorders. Transl. Psychiatry 11, 19 (2021).
Liu, H. et al. ASH1L mutation caused seizures and intellectual disability in twin sisters. J. Clin. Neurosci. 91, 69–74 (2021).
Bintu, L. et al. Dynamics of epigenetic regulation at the single-cell level. Science 351, 720–724 (2016).
Larsen, S. B. et al. Establishment, maintenance, and recall of inflammatory memory. Cell Stem Cell 28, 1758–1774.e8 (2021).
Stern, S., Kirst, C. & Bargmann, C. I. Neuromodulatory control of long-term behavioral patterns and individuality across development. Cell 171, 1649–1662.e10 (2017).
Hergenreder, E. et al. Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02031-z (2024).
Campbell, R. R. & Wood, M. A. How the epigenome integrates information and reshapes the synapse. Nat. Rev. Neurosci. 20, 133–147 (2019).
Mews, P. et al. From circuits to chromatin: the emerging role of epigenetics in mental health. J. Neurosci. 41, 873–882 (2021).
Grandi, F. C., Modi, H., Kampman, L. & Corces, M. R. Chromatin accessibility profiling by ATAC-seq. Nat. Protoc. 17, 1518–1552 (2022).
Hrvatin, S. et al. Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat. Neurosci. 21, 120–129 (2018).
Nott, A., Schlachetzki, J. C. M., Fixsen, B. R. & Glass, C. K. Nuclei isolation of multiple brain cell types for omics interrogation. Nat. Protoc. 16, 1629–1646 (2021).
Azizi, E. et al. Single-cell map of diverse immune phenotypes in the breast tumor microenvironment. Cell 174, 1293–1308.e36 (2018).
Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: large-scale single-cell gene expression data analysis. Genome Biol. 19, 15 (2018).
Wolock, S. L., Lopez, R. & Klein, A. M. Scrublet: computational identification of cell doublets in single-cell transcriptomic data. Cell Syst. 8, 281–291.e9 (2019).
Levine, J. H. et al. Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis. Cell 162, 184–197 (2015).
Phillips, J. W. et al. A repeated molecular architecture across thalamic pathways. Nat. Neurosci. 22, 1925–1935 (2019).
Finak, G. et al. MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol. 16, 278 (2015).
Fang, Z., Liu, X. & Peltz, G. GSEApy: a comprehensive package for performing gene set enrichment analysis in Python. Bioinformatics 39, btac757 (2023).
Glasner, A. et al. Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies. Nat. Immunol. 24, 1020–1035 (2023).
Dann, E., Henderson, N. C., Teichmann, S. A., Morgan, M. D. & Marioni, J. C. Differential abundance testing on single-cell data using k-nearest neighbor graphs. Nat. Biotechnol. 40, 245–253 (2022).
Keenan, A. B. et al. ChEA3: transcription factor enrichment analysis by orthogonal omics integration. Nucleic Acids Res. 47, W212–W224 (2019).
Yao, Z. et al. Whole mouse brain transcriptomic cell type atlas — 10x scRNAseq whole brain (dataset). NeMO https://assets.nemoarchive.org/dat-qg7n1b0 (2023).
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